What is synergism in pharmacology?

SYNERGISM When the combined effect of two drugs is greater than the algebraic sum of their individual effects, it is called as synergism. It results in either potentiation of the action of the drugs or prolongation of it's therapeutic effects.

Synergism occurs when two drugs act at different sites or when one drug alters the pharmacokinetics of the other drug.
Examples - Levodopa and Carbidopa (Carbidopa prevents peripheral metabolism of Levodopa allowing it's entry in brain in greater amounts). Other example is - synergistic

combination of antihypertensives like Beta-blockers and diuretics like frusemide (they act at different sites). Another very interesting example is combination of sulfamethoxazole and trimethoprim , if acting individually both of them are bacteriostatic but when in combination (known as Cotrimoxazole) they become bactericidal ( you can read about them in detail in chapters dealing with Antimicrobial agents).


    For more details regarding the conference please visit:          https://medicinalchemistryconferences.com/

   Regards                           

   Ferruccio Steven | Program Manager | Pharmacology 2020
   Larix International Pte Ltd
   Contact: +65 31655042
   WhatsApp: +65 3158 6820
    Email: ferrucciosteven@gmail.com 

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